I am just getting into that period myself actually. It is so interesting to see one of, if not the first major social and religous upheavals in the whole world. I am really not a fan of Akhenaten though, and often use the word heretic instead of his name. I swear I have the mind of an Ancient Egyptian in the body of a 21st century student! lol
Umm, i believe that Mesopotamia holds both of those distingsions. The social would be the establishment of the kingship over control of the temples and cities dating to around 2900 BCE. Prior to this date the cities of Sumer and Mesopotamia were centered around temple rule.
Another social upheaval could be considered with the establishment of the Akkadian Empire ca. 2334 BCE by Sargon the Great.
As for religious upheaval umm try Sargon's grandson Naram-Sin, and his establishment of the "divine king" ca. 2254 BCE. He was the first king of Mesopotamia to deitifed himself, as the God of Aagde.